Publication details

Title
Micronutrients supplementation and nutritional status in cognitively impaired elderly persons: A two-month open label pilot study.
Authors
Von Arnim,C. A. F.;Dismar,S.;Ott-Renzer,C. S.;Noeth,N.;Ludolph,A. C.;Biesalski,H. K.
Publication Year
2013
Abstract
Background: Malnutrition is a widespread problem in elderly people and is associated with cognitive decline. However, interventional studies have produced ambiguous results. For this reason, we wanted to determine the effect of micronutrient supplementation on blood and tissue levels and on general nutritional status in persons with mild or moderate cognitive impairment. Methods. We performed a 2-month, open-label trial, administering a daily micronutrient supplement to 42 memory clinic patients with mild cognitive deficits. Blood levels of antioxidants, zinc, and B vitamins were determined before and after supplementation. In addition, we assessed metabolic markers for B vitamins and intracellular (buccal mucosa cell [BMC]) antioxidant levels. Nutritional status was assessed by using the Mini Nutritional Assessment (MNA). Results: Blood levels of B vitamins, folic acid, lutein, (beta)-Carotene, -Carotene, and -Tocopherol increased significantly. Decreases in homocysteine levels and the thiamine pyrophosphate effect and an increase in holotranscobalamin were observed. We found no increase in intracellular antioxidant levels of BMC. The MNA score in subjects at risk for malnutrition increased significantly, mainly owing to better perception of nutritional and overall health status. Conclusions: Micronutrient supplementation improved serum micronutrient status, with improved metabolic markers for B vitamins but not for intracellular antioxidant status, and was associated with improved self-perception of general health status. Our data underline the necessity of determining micronutrient status and support the use of additional assessments for general health and quality of life in nutritional supplementation trials. (copyright) 2013 von Arnim et al.; licensee BioMed Central Ltd.
Journals
Nutr J.
Volume
12
Issue
1
Startpage
1-
Endpage
16
Booktitle
Editors
City
Publisher
Issnisbn
1475-2891
Reflist
0
Doi
doi:10.1186/1475-2891-12-148
Pmid
PMID: 24237850
Keywords
aged;blood;blood level;cheek mucosa;cognitive defect;diet supplementation;health;health status;hospital;human;intervention study;malnutrition;memory;mucosa cell;nutritional assessment;nutritional status;open study;patient;pilot study;quality of life;risk;????
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