Publication details

Title

Predictive and prognostic value of LPS-stimulated cytokine secretion in metastatic non-small cell lung cancer.

Authors

Vlachostergios,P. J.;Gioulbasanis,I.;Ghosh,S.;Tsatsanis,C.;Papatsibas,G.;Xyrafas,A.;Hatzidaki,E.;Vasiliou,C.;Kamposioras,K.;Agelaki,S.;Margioris,A. N.;Nasi,D.;Georgoulias,V.;Papandreou,C. N.

Publication Year

2013

Abstract

Objective: Cancer patients usually develop malnutrition which may alter their innate immune system integrity. The aim of this study was to investigate the clinical relevance of chemokine response after lipopolysaccharide (LPS)- stimulation in metastatic non-small cell lung cancer (NSCLC). Methods: Blood samples from metastatic NSCLC patients were incubated with LPS before the onset of systemic therapy. Interleukin (IL)-6 and IL-8 levels at baseline and after LPS-stimulation were measured and the fold change compared to baseline levels was evaluated as the stimulation index for each cytokine per patient. Results were correlated with sex, age, smoking status, histologic subtype, performance status (PS), albumin, Mini Nutritional Assessment (MNA) status and clinical outcomes. Results: Totally 103 patients were evaluated. Mean ((plus or minus)SD) stimulation index was 37.6 ((plus or minus)57.8) for IL-6 and 76.7 ((plus or minus)133.4) for IL-8. The disease control rate after firstline chemotherapy was 44/80 (55 %) and the mean ((plus or minus)SD) progression-free survival (PFS) and overall survival (OS) were 4.2 ((plus or minus)3.9) and 9.2 ((plus or minus)1.1) months, respectively. MNA, PS, albumin, IL-6 and IL-8 stimulation indices were univariately associated with PFS and OS. IL-8 stimulation index emerged as an independent predictor of both PFS and OS, along with PS, and albumin levels. Conclusion: The extent of IL-6 and IL-8 stimulation after ex vivo induction with LPS is an important predictor of clinical outcome in metastatic NSCLC patients. (copyright) Federacion de Sociedades Espanolas de Oncologia (FESEO) 2013.

Journals

Clin Transl Oncol.

Volume

15

Issue

11

Startpage

903-

Endpage

909

Booktitle

Editors

City

Publisher

Abstract Link

www.ncbi.nlm.nih.gov/pubmed/23463594

PDF Link

link.springer.com/article/10.1007%2Fs12094-013-1021-5

Issnisbn

1699-048X

Reflist

0

Doi

doi:10.1007/s12094-013-1021-5

Pmid

PMID: 23463594

Keywords

albumin;antineoplastic agent;interleukin 6;interleukin 8;lipopolysaccharide;adult;aged;article;body mass;cancer chemotherapy;cancer control;cancer prognosis;cytokine release;female;follow up;hospitalization;human;infection;lung non small cell cancer;lung ????