Publication details

Title
Inflammation, functional status, and weight loss during recovery from cardiac surgery in older adults: A pilot study.
Authors
Dimaria-Ghalili,R. A.;Sullivan-Marx,E. M.;Compher,C.
Publication Year
2013
Abstract
Objective: To determine the nutritional, inflammatory, and functional aspects of unintentional weight loss after cardiac surgery that warrant further investigation.Research Methods and Procedures: Twenty community-dwelling adults > 65 years old undergoing cardiac surgery (coronary artery bypass graft [CABG] or CABG + valve) were recruited for this prospective longitudinal (preoperative and 4-6 weeks postdischarge) pilot study. Anthropometrics (weight, standing height, and mid-arm and calf circumference), nutritional status (Mini-Nutritional Assessment [MNA]), appetite, physical performance (timed chair stand), muscle strength (hand grip) and functional status (basic and instrumental activities of daily living), and inflammatory markers (plasma leptin, ghrelin, interleukin [IL]-6, high-sensitivity[hs] C-reactive protein, and serum albumin and prealbumin) were measured.Results: Participants who completed the study (n = 11 males, n = 3 females) had a mean age 70.21 +/- 4.02 years. Of these, 12 lost 3.66 +/- 1.44 kg over the study period. Weight, BMI, activities of daily living, and leptin decreased over time (p < .05). IL-6 increased over time (p < .05). Ghrelin, hs-CRP, and timed chair stand increased over time in those who underwent combined procedures (p < .05). Grip strength decreased in those who developed complications (p = .004). Complications, readmission status, and lowered grip strength were found in those with low preoperative MNA scores (p < .05).Conclusion: After cardiac surgery, postdischarge weight loss occurs during a continued inflammatory response accompanied by decreased physical functioning and may not be a positive outcome. The impacts of weight loss, functional impairment, and inflammation during recovery on disability and frailty warrant further study.
Journals
Biol Res Nurs.
Volume
Issue
Startpage
Sept 19 [Epub ahead of print]
Endpage
Booktitle
Editors
City
Publisher
Issnisbn
1552-4175; 1099-8004
Reflist
0
Doi
doi:10.1177/1099800413503489
Pmid
PMID: 24057224
Keywords
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